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Moreover, some of these viral peptides are recognized by CD8+ T cells, with a fraction of these cells also recognizing a homologous GAD sequence (159)
REDEFINE 1 did randomize both monotherapy arms within one study, and REDEFINE 5 compares the combination against semaglutide alone but neither delivers a headline cagrilintide-alone-versus-semaglutide-alone verdict
Within the SELECT population with BMI 30 kg m 2 or 27 kg m 2 with at least one obesity-related comorbidity, the mean weight loss was 14.9% at week 68, compared with 2.4% with placebo 14
Personalized risk stratification tools may also help guide safer and more individualized use of GLP-1RA therapy in clinical practice
