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To induce acute liver injury, 8-week-old NSI mice received two consecutive intraperitoneal injections of DMN (7 mg/kg, Sigma, 1.0% dissolved in saline)
In a study published in the Bulletin of Experimental Biology and Medicine (2003), Epithalon increased telomerase activity by 2.4-fold in human pulmonary fibroblasts and extended the replicative lifespan of these cells beyond the Hayflick limit (passage 44 vs
Phosphorylation of Akt leads to activation of TOR, a molecular sensor of metabolism and cellular homeostasis (Wullschleger et al., 2006)
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