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It helps many patients eat less, improve blood sugar control, and lose significant weight (Reference)
Collectively, these results indicate that TRIP12 interacts with OTUD5 and promotes its ubiquitylation and degradation
The recommended approach is to try conservative management strategies first (cool compresses, antihistamines, clothing changes), then consider dose adjustment if symptoms persist beyond 4 weeks, and only discuss discontinuation if symptoms are severe and unresponsive to other interventions
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