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To further groups of five anaesthetized rats, different doses of the peptides formulated in the Axcess vehicle comprising a mixture of 50 mg sodium chenodeoxycholate and propyl gallate (2:1 wt:wt) were dissolved in water and instilled by injection directly into the intestinal lumen of the anaesthetised rats using an insulin syringe with a 30 gauge needle (t = 0 min)

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Its principal scientific legacy is the MC4R-mediated erectogenic effect that led to PT-141 development