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Amphetamine enters presynaptic neurons by passive diffusion and through plasma membrane monoamine transporters, including the dopamine transporter (DAT) in dopaminergic neurons, the norepinephrine transporter (NET) in adrenergic neurons, and the serotonin transporter (SERT) in serotinergic neurons

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When intracellular Ca 2+ levels rise the calmodulin subunits have an increased affinity for eNOS and nNOS

These limitations drove the development of amylin analogs synthetic peptides with the biological activity of amylin but with improved stability and pharmacokinetic profiles