We also observed that mean enrichment of a substrate decreases monotonically with increasing Hamming distance to procaspase-1, consistent with our hypothesis that cleavage activity on single-residue substitutions is predictive of cleavage activity on higher-order combinations of substitutions (Supplementary Fig
The study indicates this may not be because the patients aren't producing enough glutathione, it may be because glutathione is being used at a higher rate in patients with type II diabetes
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