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FIGURE 4 This is complicated because as a polar, charged tripeptide, transport of GSH is significantly inhibited by the blood-brain barrier (BBB), thus limiting effective delivery to brain-resident immune cells such as microglia which are central drivers of neuroinflammatory pathology (Valdovinos-Flores and Gonsebatt, 2012
Paluch AE, Boyer WR, Franklin BA, Laddu D, Lobelo F, Lee DC, et al
Glutathione supplements are effective when using 50 600 mg once daily dose
Aoki K, Terauchi Y
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