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Following FOXO4 displacement, the released p53 undergoes nuclear export and mitochondrial translocation, activating the intrinsic apoptosis pathway via BAX upregulation and BCL-2 downregulation, culminating in caspase-3 cleavage and apoptotic cell death
doi: 10.1016/j.phymed.2025.157164 227 YuanSWangYLiZChenXSongPChenAet al
Interestingly, one 2012 study found that people with acne who took 210 milligrams of silymarin per day for 8 weeks experienced a 53% decrease in acne lesions
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