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Although a significantly elevated renal CAT activity in 6- and 16-week old, 22 and older SHR 8, 23 has been reported before, this is the first time that altered renal CAT expression and activity has been reported in pre-hypertensive SHR

Caldern-Salinas JV, Muoz-Reyes EG, Guerrero-Romero JF, Rodrguez-Morn M, Bracho-Riquelme RL, Carrera-Gracia MA, et al

And the larger clinical trial evidence (STEP 9 in knee osteoarthritis patients, the SLIM LIVER study) supports the view that the disproportionately larger loss of fat relative to LBM results in improved mobility and physical function, even when absolute LBM declines

doi: 10.2337/dbi18-0008 48 JastreboffAMAronneLJAhmadNNWhartonSConneryLAlvesBet al