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Frequency: Administer once daily or EOD for the first week of study

This creates a powerful, dual-action synergistic effect: the L-Carnitine component ensures a steady supply of acetyl-CoA by transporting fats into the mitochondria, while the fumarate component accelerates the Krebs cycle's ability to process that fuel into usable cellular energy

In the gut, HFD significantly increased permeability, induced a major shift in microbiota composition (ileum and colon) from t=8w and associated with circulating gut-derived metabolite changes (short-chain fatty acids and bile acids)