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Yes, continuous, high-dose administration of any secretagogue can potentially lead to receptor downregulation
Neither is a proxy for quality
FDA has evaluated the following bulk drug substances and determined that there is a clinical need for outsourcing facilities to compound drug products using these bulk drug substances under section 503B of the FD&C Act: One key condition: Facility generally cannot compound drugs using bulk drug substances unless that substance appears on the FDA's '503B Bulks List' (substances for which there is a demonstrated clinical need) or the compounded drug is on the FDA's active drug shortage list
Providers must carefully weigh the benefits and risks of compounded medications and ensure compliance with FDA regulations to avoid potential legal and safety issues
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