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The selectivity of the blood-brain barrier, which limits the passage of some antioxidants such as vitamin E, and the excessive consumption of polyunsaturated fatty acids are two factors that make the central nervous system particularly susceptible to the action of ROS (Shukla et al

It can reduce the absorption of oral medications, including oral contraceptives, so additional contraceptive methods should be used for 4 weeks after starting Zepbound or after dose increases