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1 As summarized in this review, resistance is not solely dictated by tumor-intrinsic genetic alterations but is shaped by a dynamic interplay among clonal evolution, signaling rewiring, epigenetic remodeling, altered DNA damage repair, metabolic adaptation, dysregulated cell death, TCP, microenvironmental remodeling, and hostmicrobetumor interactions

European Journal of Applied Physiology, 99(2), 193199

This finding is consistent with the broader observation that GHS-R1a receptors are expressed in multiple tissues beyond the pituitary, including kidney, heart, and immune cells, suggesting pleiotropic protective functions

It is important for the proper metabolism of all essential amino acids and the transfer of cellular energy in the citric acid, or Krebs cycle