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These changes can persist even with reasonable diet and exercise habits

Rahaman MM, Hossain R, Herrera-Bravo J, et al

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Healthcare providers can assess whether mood changes represent: Medication-related effects potentially requiring dose adjustment or discontinuation (per FDA guidance, Zepbound should be discontinued if suicidal thoughts or behaviors occur) Underlying psychiatric conditions needing specific treatment Physiological factors such as thyroid dysfunction or nutritional deficiencies Situational stressors benefiting from counseling or support services For patients with established mental health care, coordination between prescribers becomes critical