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Several viral infections, and the progression of virus-induced diseases, especially those associated with COVID-19, are characterized by an alteration in the intracellular redox balance (144, 145) and respiratory diseases, known risk factors for developing severe illness and death in patients with SARS-CoV-2 and COVID-19 disease

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308 Although this tolerant state is initially reversible upon drug withdrawal, representing a resensitization exit route, prolonged persistence under treatment pressure increases the probability of acquiring irreversible genetic alterations, driving an alternative exit toward stable, mutation-driven resistance and tumor relapse