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However, AAOS and OARSI have not included duloxetine in their OA management guidelines, 3,24 as more large-scale longitudinal studies to further investigate the safety and efficacy for OA treatment have to be performed

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Semaglutide activates GLP-1 receptors alone, while tirzepatide activates both GLP-1 and GIP receptors, often producing stronger insulin sensitivity gains in clinical trials

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