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The regain problem The main theory for why the majority of patients regain weight so rapidly when they stop taking medication is because the regions of the brain relating to appetite are still dysregulated, priming the person to overconsume
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Wegovy acts on GLP-1 receptors primarily in the gastrointestinal tract, pancreas, and specific brain regions involved in appetite regulation, whilst melatonin acts on melatonin receptors in the suprachiasmatic nucleus and other areas regulating circadian rhythms
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