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The benefits are genuine, but they flow through the vasculature, the nervous system, and secondary mediators more than through the organs working cells, a distinction that matters when designing drugs meant to target these tissues

In early studies, the addition of oral L-carnitine or propionyl-L-carnitine to pharmacologic therapy for chronic stable angina modestly improved exercise tolerance and decreased electrocardiographic signs of ischemia during exercise testing in some angina patients (59-61)

Many clients report improvements in sleep, energy, or workout recovery within a few weeks, while changes in body composition, skin quality, and metabolic markers typically build over several months of consistent treatment

Medications that have been reported to have some benefit are summarized in Table 3