Patients in the hypertonic saline group experienced more effective diuresis, shorter hospital stays, and a reduced rate of re-admission: LaFreniere G 2017: Effects of hypertonic saline solution on body weight and serum creatinine in patient with acute decompensated heart failure This is a prospective cohort study describing 47 patients with refractory acute decompensated heart failure treated with hyperdiuresis at Quebec University Hospital Centre
Particularly notable is that nearly half of participants on the high dose achieved at least 30% body weight reduction
If you cant administer your medication on your usual day and can do so within a few days, it shouldnt be a problem
Kaku K, Watada H, Iwamoto Y, Utsunomiya K, Terauchi Y, Tobe K, Tanizawa Y, Araki E, Ueda M, Suganami H, Watanabe D, Tofogliflozin 003 Study Group