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Several factors can contribute to this more vulnerable environment: declining estrogen levels during menopause lower muscle mass during rapid weight loss reduced resistance training activity aggressive calorie restriction reduced protein intake lower mechanical loading through movement and exercise This does not mean GLP-1 medications directly cause osteoporosis

Diet: It is important to emphasize that GLP-1s work only if the patient is on a calorie deficit - about 1600 calories per day

Avoid use during pregnancy or breastfeeding unless your provider decides the benefits outweigh the risks

For GLP-1 patches, the side effect profile has a key difference from injections: the addition of potential skin reactions