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We will further look into this and explore how we can help patients with addiction, potentially with GLP-1, Lange said, also adding that it has to be addressed in a scientific, and obviously also from a regulatory perspective, very rigorous way so we can really see the potential impact of GLP-1 in that space. However, in response to questions from Biospace, a Novo spokesperson said that Lange was referring to the already ongoing work studying semaglutide on liver damage and alcohol use in its phase 2 trial, and that the company has no plans to study the drug in broader addiction indications
Lushchak VI
Decreases in LCAs and MCAs in E4s may reflect poor mitochondrial FAO capacity or alternatively increased cellular reliance on FAs to support bioenergetics in the cerebrovasculature
If you are losing weight consistently and managing side effects well at a lower dose, there is no clinical reason to increase further
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