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The drug is highly effective but can cause weight gain, muscle wasting, and other serious side effects
Nonetheless, these transient interactions are clearly essential for receptor activation, with mutation of the majority of residues within the TMD cavity decreasing exendin-P5 efficacy, but not affinity
doi: 10.3389/fimmu.2020.00348 36 ChandwaskarRAwasthiA
GLP-1 & tirzepatide bottom line: Prevent malnutrition, and muscle wasting is unlikely
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