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Several ionic mechanisms such as non-selective cation channel, voltage-dependent potassium channel, and TRPC5 channel may be associated with activation of GLP-1R-induced electrophysiological effects (Figure 1A)

Aghdam MS, Asghari M, Farmani B et al (2012) Impact of postharvest brassinosteroids treatment on PAL activity in tomato fruit in response to chilling stress

This hormone is released by the gut after we eat and serves both to lower blood sugar (thus its use in type 2 diabetes) and provides a feeling of satisfaction

We may speculate that a larger reduction of plasma aldosterone in the patients with advanced CKD seen in our study could be caused by a higher local activity of RAAS due to kidney dysfunction