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Early clinical studies with Melanotan II unexpectedly identified potent pro-sexual and pro-erectile effects in male volunteers effects mediated centrally through the melanocortin system rather than through peripheral vascular mechanisms which prompted the development of PT-141 as a purpose-designed, more selective CNS melanocortin agonist optimised for sexual behaviour research and clinical application
Evidence also supports their neuroprotective potential, with improved cognitive function in individuals with AD or MCI, and motor symptom relief in individuals with Parkinsons disease
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