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The peptide suppresses nuclear factor-kappa B (NF-kB) activation, a master regulator of inflammatory gene expression
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For example, Wegovy is a brand-name drug approved in 2021, while phentermine is a generic drug approved in 1959
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However, preclinical studies demonstrate therapeutic effects with once-daily or even less frequent administration, suggesting tissue distribution, receptor binding, or cellular signaling effects extend beyond plasma clearance
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