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While injectable GLP-1 medications generally have no direct pharmacokinetic interaction with levothyroxine, there are important considerations regarding oral semaglutide and indirect effects that warrant attention
Whilst routine pancreatic enzyme testing is not indicated in asymptomatic patients, clinicians should maintain a low threshold for investigation if symptoms develop
a Kansas City Cardiomyopathy Questionnaire clinical summary score (KCCQ-CSS) of less than 90 points, and a six-minute walk distance of at least 100 meters
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