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This activation promotes the phosphorylation of GSK3, which suppresses the expression of programmed cell death protein 1 (PD-1), thereby enhancing the anti-tumor activity of T cells ( 3.3 HMGCR exerts tumor inhibition through the Hippo pathway The Hippo pathway primarily regulates cell proliferation ( HMGCR serves as the rate-limiting enzyme of the MVA pathway, catalyzes the conversion of HMG-CoA to mevalonate, and provides precursors for the synthesis of isoprenoids such as geranylgeranyl pyrophosphate (GGPP)
10.1111/j.1464-5491.2011.03387.x 83
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