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Insolation, a measure of the intensity of solar energy over our city during a specific timeframe, is more than twice as high during the summer solstice on June 21st than it is on the winter solstice December 21 st here in Carmel

Even if it is still unclear whether OS is a primary or a secondary cause of neurodegeneration in ALS, overwhelming evidence indicates the pathological role of OS, and alterations in KEAP1 and NRF2 expression and in KEAP1-NRF2 activity may explain the progressive MN degeneration and death associated with ALS [170]

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