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In the 1940s, Lilly was one of the first companies to develop a method for the mass production of penicillin , which was one of the most frequently used drugs during WWII
Then, the active forms of GLP-1 are extremely susceptible to the catalytic activity of the proteolytic enzyme dipeptidyl peptidase-4 (DPP-4), resulting in the abundant inactivated GLP-1 (936) or GLP-1 (937) amide constituting 6080% of total GLP-1 in circulation
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