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How to drink collagen supplement properly: Mix it with cold or room-temperature liquids, as hot drinks can denature the protein

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Notably, the depletion of anti-HMGB1 neutralizing antibody or arginine catabolism enzyme (AGRE) mitigates macrophage inflammatory responses, suggesting that restricting HMGB1 expression may be a potential approach for managing macrophage inflammation (103, 104)